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Although excessive sugar intake is considered a major cause of T2DM [2, 28], the exact mechanism by which high glucose causes -cell failure remains unclear

In: UpToDate , Basow, DS (Ed), Waltham, MA

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While the primary outcomes of these trials did not specifically assess suicidal ideation or behaviors, the significant weight loss achieved with tirzepatide could have positively impacted patients psychological well-being, indirectly reducing the risk of mental health-related adverse outcomes

--- The Dosing Protocol The study used a locally administered protocol, injecting near the joint rather than systemic subcutaneous injection