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This discovery provided a novel treatment strategy for diseases related to mis-splicing

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1.73 g 0.52 g

thus, the final dose for each arm (5, 10, and 15 mg) was respectively achieved after four, twelve, and twenty weeks from randomization with a considerable difference in time of exposure to TZP 5 mg (36 weeks), TZP 10 mg (28 weeks), TZP 15 mg (20 weeks)