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Subjects with obesity: significantly higher NNMT activity in adipose tissue and liver

Parry-Williams et al

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T2DM itself is known to disrupt the gut microbiome, often leading to reduced diversity and a decline in beneficial genera like Bifidobacterium, Bacteroides, and Faecalibacterium, with increases in potentially harmful genera such as Ruminococcus, Fusobacterium, and Blautia