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Interestingly, TAM were shown to secrete several pro-angiogenic cytokines and growth factors, such as VEGF (4446), MMP (4648), IL-10 (40, 46, 47, 49, 50), IL-8 (45, 46), FGF2 (45, 51, 52) and placental growth factor (PlGF) (52), allowing them to modulate angiogenic pathways

Acknowledgments The authors thank the biochemical drugs engineering and technological research center of Anhui for the help in performing experiments

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