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Contact Dermatitis, 25: 276-283

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By contrast, genuinely contact-site-oriented strategies would aim to modulate defined MAM-tethering or signaling complexes, such as the IP 3 RGRP75VDAC1 Ca 2+ transfer axis, MFN2-dependent ERmitochondria juxtaposition, or the VAPBPTPIP51 tethering interface, all of which are increasingly recognized as major determinants of Ca 2+ exchange, bioenergetics, and mitophagy initiation in stressed cells (84, 94)

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