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The SURMOUNT trials showed tirzepatide at 15 mg achieving 15% to 21% weight loss by week 72, compared to semaglutide at 2.4 mg achieving approximately 15% by week 68
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An increased intestinal absorption of bile acids stimulates the secretion of FGF19 from intestinal enterocytes (26), and increasing circulating levels of both bile acids and FGF19 inhibit hepatic bile acid synthesis, as mentioned above
A.MercierN
doi: 10.1172/JCI88878
Tirzepatide (dual GLP-1/GIP receptor agonist): In the SURMOUNT-1 trial, participants on the highest tirzepatide dose (15 mg) achieved approximately 22.5% body weight reduction at 72 weeks
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