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A panel of reference ligands representing diverse chemotypes including TT-OAD2, PF-06882961 (danuglipron), LY3502970 (orforglipron), CHU-128, GSBR-1290 (aleniglipron), and AZD5004 (Figure 2) was used to derive the ligand-centered models described below

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This is even more commonplace if other techniques fail to produce the desired results

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