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One study examined treatment periods that lasted more than 36 weeks

A preliminary study of NASH was conducted with F2-3 fibrosis patients treated with selonsertib at 6 mg or 18 mg orally alone or in combination with simtuzumab (125 mg subcutaneously weekly) or simtuzumab alone for 24 weeks

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Non-arteritic anterior ischemic optic neuropathy (NAION) is characterized by optic nerve ischemia leading to abrupt vision loss, yet its pathophysiology remains inadequately understood [96]

Phase 3 TRIUMPH-4 results (68 weeks): 9mg dose: 26.4% average weight loss (29.1 kg) 12mg dose: 28.7% average weight loss (32.3 kg) Placebo: 2.1% average weight loss The 12mg retatrutide group lost an average of 71.2 pounds

From a dosing chart perspective, B12 addition does not change the tirzepatide dose itself