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Overall, while GLP-1 RAs are a breakthrough for adolescent obesity, judicious use is key

Autoimmun Rev (2021) 20(2):102736

While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions

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Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans