The dose is escalated gradually over several months, starting at 2.5 mg and increasing up to a maximum of 15 mg, allowing the body to adjust and minimising the severity of side effects
Tirzepatide 15 mg (Mounjaro/Zepbound) produced 22.5% mean weight loss at 72 weeks in SURMOUNT-1 (N=2,539) [14]
Subsequently, N -deprotection is performed, allowing for the final conjugation of PalOH to complete the synthesis (Scheme )
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Peptide lipidation stabilizes structure to enhance biological function