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Further supporting evidences come from the clinical studies of male pseudohermaphrodites with an inherited DHT deficiency due to 5 -reductase-2 gene mutations from the Dominican kindred, the largest pedigree in the world

PRX2 has been found to be secreted by inflammatory cells and is elevated in synovial fluids and serum in patients with rheumatoid arthritis (Szabo-Taylor et al

Meanwhile, the expression of p16 in the glomeruli is linked to the occurrence of proteinuria associated with DN

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