While there are big reasons for this, like well-publicized research about the impact alcohol has on health and a general decline in social activities among Gen Z, one connection thats only just getting some attention is that between GLP-1 medications, like semaglutide and tirzepatide, and alcohol use
Have antioxidant properties
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(5) Wessells H, Fuciarelli K, Hansen J, Hadley ME, et al
Whilst berberine is generally considered safe when used appropriately, it is not without potential adverse effects and important safety considerations