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Additionally, despite substantial weight loss, systematic cardiovascular outcomes trials have not been completed to establish whether GLP3 reduces major adverse cardiovascular events

Promising, worth studying, but the society does not recommend routine use outside specialist settings, and says it should ideally be prescribed within research frameworks

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Semaglutide, the class anchor, is a GLP-1 mono-agonist

GLP-1 medications are unsuitable for individuals with: A personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia type 2 (MEN 2) They should also be used with caution in patients with severe gastrointestinal disease