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However, these interventions have not been tested in a robust, large scale randomized trial and conclusions from prior assessment are often contradictory [118]

Whats driving it

Beyond these shared roles, their physiological functions diverge: GIP facilitates efficient energy storage in adipocytes and plays a crucial role in bone metabolism, whereas GLP-1 exerts pleiotropic effects on the heart, kidney, and liver 6,7

It is the first serious bet that incretins are central nervous system medicine

Ideally, these factors should have been reported and included in the analysis for both AOM and non-AOM groups

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