10.3389/fncel.2019.00230 Front
The transition between fibrous and myxoid zones is often abrupt
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Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig
The hormone prevents the liver from releasing sugar into the bloodstream, which would otherwise contribute to fat buildup
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