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A pooled analysis of the STEP 1-3 clinical trials found that people taking semaglutide 2.4 mg experienced: 4 Nausea in 43.9% of users Diarrhoea in 29.7% of users Constipation in 24.2% of users Vomiting in 24.5% of users For someone without IBS, these side effects are usually temporary and ease within the first few weeks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 243.Schrauwen P

This range balances adequate pituitary stimulation against practical considerations of cost, side effect tolerance, and physiologic limitations