sustain 6 trial semaglutide Semaglutide. Tirzepatide. The names dominate headlines: “Game-changing weight loss injections.” “A revolution in diabetes care.” But beyond the buzz, here's what the evidence says: Glycemic control: Landmark trials (SURPASS, SUSTAIN) show significant FLOWing with the SemagluTIDE —

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Because retatrutide has not yet received regulatory authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), it is not legally available for prescription in the UK outside of authorised clinical trials

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(2016) 11:e0146509

5,6 Globally, GI disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), gastroesophageal reflux disease (GERD), constipation, dyspepsia, and peptic ulcers represent a major health burden

12 , 18 , 21 , 24 It is also important to acknowledge that the influence of other unrecognized or under-reported GI motility disorders may have been underestimated in the included populations