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Theoretical concerns are not proof of harm, but they identify areas off-target SAM effects, signalling-pathway impacts, and uncharacterised interactions that require study before any conclusion about human safety could be drawn

18 As such, the prospects of comprehensively elucidating the mechanism of SGLT-2is and GLP-1RAs interacting with BBB are promising, through which corresponding strategies for the prevention and treatment of DM, AD, PD and CVD can be developed

A 2024 review found that people with kidney stones who took GLP-1 agonists had higher citrate, but also lower urine pH, higher sodium, uric acid and oxalate compared to people who did not take these medications