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For mTYR, the narrow dual copper-binding site makes it more difficult for arbutin, which has two rings, to fit, especially in the MD-stable conformation of Arbutin_b, where the number of hydrogen bonds between arbutin and the pocket is much lower than in other conformations (Table 2)

is an advisor to Allogene Therapeutics, Asher Biotech, AstraZeneca, Merus, JNJ and Scenic Biotech

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Not including the 11 th Project, a PPS can pick a maximum of four Domain 2 projects, four Domain 3 projects, and two Domain 4 projects

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