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The cardinal signs of PD are motor impairments such as resting tremor, bradykinesia, muscular rigidity, postural instability (Jankovic, 2008

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Immunotherapy (2016) 8(8):889906

237 detected metabolic responses related to perturbations in glutamine metabolism in 47 independent breast cancer-derived cell lines, meaning that the inhibition of xCT promotes an adjustment in glutamine metabolism, which indirectly contributes to the import of cysteine through the exchange with glutamine-derived glutamate through xCT