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Front Neurosci 13:962

When activated, mast cells release a complex array of mediators: histamine, tryptase, leukotrienes, prostaglandins, and a range of cytokines

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To address this challenge, we previously developed a pathway network-based approach that identifies shared molecular pathways and potential therapeutic targets for comorbidities through the reconstruction and analysis of Disease-Disease pathway-pathway comorbidity networks 19