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Beyond GLP-1 for weight loss and diabetes, some GLP-1s are approved for addressing conditions including cardiovascular risk, sleep apnea and chronic kidney disease in people with Type 2 diabetes
Because Ozempic was originally designed to lower blood sugar in people with type 2 diabetes, hypoglycemia is a potential side effect
2 Institute of Virology, Hubei University of Medicine, Shiyan, Hubei, 442000, Peoples Republic of China *These authors contributed equally to this work Correspondence: Jun Chen
perhaps most synonymous with weight loss programs
45.3% of participants on the highest dose lost 30% or more of their body weight TRIUMPH-4 knee osteoarthritis + obesity (Dec 2025) 28.7% weight loss at 68 weeks TRANSCEND-T2D-1 type 2 diabetes (Mar 19, 2026) A1C -2.0%, 16.8% weight loss at 40 weeks TRIUMPH-2 obesity with type 2 diabetes, nested OSA protocol (July 23, 2026) 20.8% weight loss at 12 mg over 80 weeks
However, the GLP-1 released naturally after a meal is broken down very quickly by an enzyme called DPP-4, which helps explain why it doesnt produce the same sustained effects as GLP-1 medications
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