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2014), supporting their use as a potential treatment

The cataplerotic reactions that involve conversion of PEP to pyruvate in the cytosol then pyruvate to oxaloacetate (OAA) then OAA to aspartate in the mitochondria then aspartate back to OAA in the cytosol and OAA back to PEP constitute what is referred to as pyruvate cycling

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The added ingredients target lipid metabolism and cellular function, though evidence for synergistic benefit remains mixed

Cell signalling can be disrupted by oxidative stress

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