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This process triggers a robust local inflammatory response, characterized by infiltration of neutrophils, macrophages, and T cells, as well as the release of proinflammatory cytokines such as TNF-, IL-1, and IL-6

[PubMed 19598213] 7

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UV radiation triggers melanocytes to produce more melanin, leading to uneven skin tone and stubborn dark patches

The reduction of NF-kB, STAT1, and AP-1 transcriptional activity is one of the PPAR- anti-inflammatory actions (Ricote et al

Upgrade options include Vitamin C doses up to 10 grams