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However, continues Brody, The deleterious effects of untreated moderate or severe ADHD far outweigh the relatively mild (if any) adverse effects of (prescription drug) treatment. Methamphetamine in its illegal form is never a suitable alternative to Adderall

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In these depression models, caffeine exposure was mostly chronic [32,33,34,35,36,37, 39, 41, 42], except for one study with acute exposure [40]

These are described as community-reported tolerability observations, not a controlled finding but they're consistent with how topical actives behave generally

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