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The neuroprotection facilitated by TNFR1 may operate either by gene induction or by de novo production of survival proteins during the absence of caspase 8-dependent apoptotic signals [46]

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The primary consideration is that women using hormonal contraceptives may require dose adjustment, as exogenous estrogen can increase IGF-1 binding proteins and alter the free IGF-1 fraction measured in standard assays

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Patients with a family history of cancer, pre-diabetic conditions, or cardiac concerns will be evaluated on a case-by-case basis