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Further research is ongoing to determine its long-term safety and efficacy for obesity treatment

Conversely, if you carry variants associated with higher baseline weight set-point (FTO rs9939609), you might benefit from more aggressive GLP-1 dosing paired with optimized testosterone levels to preserve muscle during a deeper calorie deficit

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Further, the expression of neurogenesis-related proteins was promoted by the activation of the cAMP/PKA and Akt/GSK3 signaling pathways through the stimulation of GLP-1R in mice (Wang et al., 2018)

Together, these mechanisms reduce the dopamine response to high-calorie foods and make your brain feel satisfied faster