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This trend accelerated with tirzepatide gaining FDA approval for type 2 diabetes under the name Mounjaro in 2022, and subsequent approval of Zepbound for chronic weight management in adults with obesity or overweight in 2023

CTSC deficiency has been shown to attenuate the severity of pancreatitis, not by inhibiting proenzyme activation in acinar cells but by reducing neutrophil infiltration into the pancreas