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Lansoprazole a Proton Pump Inhibitor Prevents IBD by reduction of oxidative stress and NO levels in the rat

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This creates a vicious cycle of local hyperuricemia-crystal deposition-microcirculatory deterioration, accelerating crystal precipitation (149151)

Passage of bile acids through the enterocyte activates FXR, which promotes the synthesis of fibroblast growth factor 19 (FGF19), which also circulates through the portal vein to the liver where it activates fibroblast growth factor-receptor 4 resulting in inhibition of bile acid synthesis

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