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By lowering the systemic inflammatory burden, LDN has shown significant efficacy in reducing the burning pain and allodynia of SFN without the heavy sedative effects of traditional nerve medications

Redox Biol (2017) 11:6139

Compared with oral administration or the extremely difficult intra-articular injection into small joints, MNs offered a minimally invasive, painless transdermal drug delivery system

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Meanwhile, the upstream regulatory mechanism eliciting an imbalance in OA matrix homeostasis needs further investigation

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