proposed a nanocluster, which integrated catalase (CAT) with MnO 2 to realize CAT-triggered oxygen release and Mn 4+ -assisted GSH exhaustion, accompanied by abundant 1 O 2 accumulation, achieving a remarkable anticancer performance characterized by GSH depletion-improved PDT (Zhu et al., 2020)
Early literature therefore portrayed SQOR primarily as a detoxifying enzyme that prevents H 2 S-mediated inhibition of complex IV, as illustrated by the severe metabolic crises seen in SQOR deficiency (Kanemaru et al., 2024
Supplementary Materials The following supporting information can be downloaded at: Table S1: Full database search strings, Table S1B: Data-charting form, Section S1C: Deduplication rules, Section S1D: Controlled exclusion reasons
Recently, a phase IIa clinical trial of ARINA-1 demonstrated positive results in adult subjects with noncystic fibrosis bronchiectasis (NCFBE) characterized by excess mucus and cough (NCT05495243)
Liver function
Both above studies suggest that MTHFR polymorphisms might enhance the environmental risks (low folate intake, traumatic stress at childhood) for MDD via the interaction between genetic and environmental factors
