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Wegovy is the only option of these three that has specifically been approved for use as a weight loss medication, only really differing from Ozempic by its recommended dosages

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As body composition changesparticularly fat lossestrogen storage and distribution shift because adipose tissue produces and stores estrogen

The stress hormone, cortisol, can interfere with thyroid hormone production

Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations (62), suggesting a role for AIP alterations in SS-resistance of sporadic GH-secreting adenomas

Feb 28 2020;26(2):247-263