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BMJ Open 2 , e000412 (2012)

247 The clinical value of bisphosphonate-based drugs (such as ibandronate, 248,249 clodronate, 250,251 pamidronate, 252,253 and zoledronate 19,22,254,255,256 ) has been shown in numerous trials of PCa (Table 3)

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During each trial, each rat was placed into the tank from one of four directions (north, south, east, or west) in a random order to prevent them from memorising a fixed escape route and to encourage them to use spatial cues

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Its effectiveness is not in doubt and the process is generally safe in clinics with qualified medical staff, but no procedure involving skin penetration is without risk of infection