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Priority research areas include: Long-term safety studies extending beyond 2-3 years Comparative effectiveness research comparing different GLP-1 RAs Studies examining optimal treatment duration and discontinuation strategies Research on predictors of treatment response Health economic analyses specific to pediatric populations Investigation of combination therapies Studies addressing health equity and access barriers Policy Implications The use of GLP-1 receptor agonists (GLP-1 RAs) for pediatric obesity presents important considerations for health policy

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Conflict of interest Authors NR-S, HR, and EN were employed by VTT Technical Research Centre of Finland Ltd