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Yamamoto M, Guo DH, Hernandez CM, Stranahan AM

As a synthetic analog of somatocrinin, CJC-1295 has high selectivity and has been suggested to have anti-aging effects by promoting cellular repair and regeneration processes

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The first is extracellular matrix biology, where fibroblast culture and rat wound-chamber studies from the Maquart and Simeon groups (1988-2000) reported stimulation of collagen synthesis, sulfated glycosaminoglycan synthesis and small proteoglycan expression, alongside upregulation of matrix metalloproteinase-2 and its tissue inhibitors, a simultaneous increase in both matrix deposition and matrix turnover

Once B12 levels are normalized, maintenance shots may be required every few months or as recommended by a healthcare provider

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice