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The assumption of proportional hazards was evaluated with the generalized Schoenfeld approach on the TriNetX platform, with aHRs recalculated for specific time frames if initial assumptions were not met

In addition, studies have shown that it also has a certain protective effect on reducing the incidence of cardiovascular disease in some high-risk groups

Currently, sulfonylureas are still listed as first-line oral hypoglycemic agents in many countries and regions

Changes in hydration, glycogen storage, organ size, and inflammation can therefore influence a reported lean-mass value

The shift from Gs to Gq effective coupling in persistently depolarised beta cells may hint at therapeutic and pathophysiological significance