The medication has a half-life of approximately five days, allowing for consistent therapeutic levels with weekly dosing
Jame-Chenarboo, F., Ng, H
In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]
Tang D, Kroemer G
Common Side Effects of GLP and GIP Supplements While GLP-1 and GIP supplements are usually easy to handle, you should know about possible side effects, such as increased heart rate
In other words, the people with access to these drugs had other protective factors against dementia