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Int J Mol Med 2017;39:102936.ArticlePubMed 57
Inhibition of SGLT-1 in the small intestine causes more glucose transport to the distal intestine and colon, resulting in greater fermentation of glucose to SCFAs by luminal bacteria and increased sustained release of GLP-1 in the distal intestine [174] (Fig
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However, many doctors are wary of microdosing GLP-1s, especially in the absence of an actual medical condition
The theory is straightforward: slower absorption means a gentler onset of the medication effects, reducing the sharp spike that can trigger bloating and nausea in sensitive individuals
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