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Secondly, physical modifications in the receptor can also constitutively activate c-MET receptor through somatic mutations

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In light of these findings, we postulated that long-term fluctuating glycemia, especially after extra carbohydrate intake, continuously and waveringly generates extra ROS, which in turn damages the pancreatic -cells

[20,21] Overview of Cancer Therapeutic Agents Chemotherapy agents can be divided into several categories: alkylating agents (e.g., cyclophosphamide, ifosfamide), antibiotics which affect nucleic acids (e.g., doxorubicin, bleomycin), platinum compounds (e.g., cisplatin), mitotic inhibitors (e.g., vincristine), antimetabolites (e.g., 5-fluorouracil), camptothecin derivatives (e.g., topotecan), biological response modifiers (e.g., interferon), and hormone therapies (e.g., tamoxifen).The agents most noted for creating cellular damage by initiating free radical oxidants are the alkylating agents, the tumor antibiotics, and the platinum compounds

(2012) 2:e134

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