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Once central sensitization develops, even removing the original trigger may not immediately resolve the pain, because the amplification occurs in the central nervous system rather than at the periphery
3.2.2 Inflammatory signaling pathways such as nuclear factor kappa B (NF-B) or p38 mitogen-activated protein kinase (MAPK) Targeting upstream master regulators of inflammation, such as the NF-B and p38 MAPK pathways, offers a strategic therapeutic approach by potentially suppressing a broad spectrum of downstream pro-inflammatory effectors implicated in tinnitus pathogenesis
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Nauck 2,3 , Joon Ho Moon 4 Endocrinology and Metabolism 2025;40(1):156-160
Check temperature periodically, especially after adjusting settings or during seasonal changes in ambient temperature