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An increasing gradient of GLP-1 cell density exists along the intestine, with higher densities in distal regions [14, 15], but GLP-1 cells are also present in the jejunum, the major site of nutrient absorption

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Synthetic small molecule SIRT1 activators Compared with natural products, synthetic SIRT1 activators offer several advantages, including defined molecular structures, high target selectivity, and stable pharmacokinetic profiles, making them a promising direction for the clinical application of SIRT1-targeted therapies

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