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Biochem Biophys Res Commun 83:10931098

Between 2 and 12% of patients receiving high-dose MTX therapy may get acute kidney injury, mostly as a result of crystal nephropathy caused by MTX and its metabolite, 7-OH-MTX

Clinical presentation and management of acromegaly in elderly patients

Oxidation of phosphatidylcholine during reperfusion produces phosphatidylcholine oxide (OxPC), which disrupts mitochondrial biological function and calcium transport and induces ferroptosis, leading to widespread cell death

Acylcarnitine also helps promote intestinal peristalsis, which has been shown to be significantly positively correlated with the defecation frequency and can relieve constipation symptoms [236]