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Potential future developments include novel delivery mechanisms, multi-receptor agonists, and a broader range of therapeutic uses for the treatment of metabolic disorders and their consequences

The proposed clinical trial endpoints are the resolution of steatohepatitis without worsening or liver fibrosis and/or improvement in liver fibrosis one stage or greater without worsening of steatohepatitis

What Happens at Steady State: Plateau Dynamics and Extended Dosing One of the most clinically significant findings from the 12mg retatrutide dosage cohort was the absence of a weight loss plateau at 48 weeks

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There was no plateau in weight loss at 46 weeks with the potential of further weight loss over a longer time period

doi: 10.1177/1479164111404257 Erratum in: Diab Vasc Dis Res