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Hydrogen easily penetrates mitochondrial membranes, reducing excessive ROS while preserving beneficial ROS signaling, protecting mitochondrial DNA, and improving membrane potential and energy production

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Lipoxygenases catalyse the addition of molecular oxygen to polyunsaturated fatty acids containing a ( cis,cis )-1,4-pentadiene system to yield an unsaturated fatty acid hydroperoxide

Distinguishing between these temporal and quantitative dimensions is critical for interpreting melatonins role in circadian regulation and aging