doi: 10.1056/nejmoa2404881 56
Whether it maintains adequate glucagon receptor activation for metabolic benefits remains unknown
GLP-1RAs activate GLP-1R similarly to GLP-1, but they are resistant to the activity of DPP-4
In one study , 1,961 adults with obesity or overweight plus at least one weight-related medical condition regained two-thirds of the weight they had lost within one year of stopping semaglutide treatment and lifestyle interventions
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