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doi: 10.1038/s41598-021-95827-5 145 LeeSYKangJMKimDJParkSHJeongHYLeeYHet al

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Practical recommendations: If desired for comfort, remove the pen from the refrigerator 1530 minutes before your scheduled injection time Allow it to reach room temperature naturallynever use external heat sources Do not use a microwave, hot water, or direct sunlight to warm the pen The pen should feel neutral to touch, not cold Some patients find that even with room-temperature injection, they experience mild discomfort

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