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A1C reduction comparison A network meta-analysis published in BMC Endocrine Disorders in 2024, analyzing 26 clinical studies, found the following A1C reductions compared to placebo: Tirzepatide 15mg: -2.24% A1C reduction Tirzepatide 10mg: -1.99% A1C reduction Tirzepatide 5mg: -1.82% A1C reduction Liraglutide 1.8mg: approximately -1.3% A1C reduction Liraglutide 1.2mg: -1.23% A1C reduction At the highest respective doses, tirzepatide reduces A1C by nearly twice as much as liraglutide

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Low vitamin B12 levels can contribute to symptoms such as fatigue, low energy, brain fog, pins and needles, or low mood

10.1186/s12944-018-0939-6 94

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