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Upon the upregulation and activation of Nrf2, the heterodimers of nuclear Nrf2 and small Maf proteins form to recognize antioxidant response elements (AREs), and then recruit key factors for transcription of Nrf2 target gene including HO-1 (Hayes et al., 2010)

The release of HGF, in conjunction with c-MET, triggers subsequent processes that result in STAT3 phosphorylation, thereby facilitating the growth of functional MDSCs [81]

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PMID 18397973

These positive effects were observed to persist into adulthood, indicating potential long-term benefits