In Fenton and Fenton-like reactions, divalent iron reacts with hydrogen peroxide to generate hydroxyl radicals, a primary source of radical formation [12]
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Oxidants in chronic kidney disease
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This platform demonstrated enhanced oral insulin bioavailability, achieving superior glycemic control with dual hypoglycemic and insulin-sensitizing effects in diabetic murine models compared to conventional intravenous administration
Our previous study using intestine-specific Zip14 KO (IKO) mice revealed that intestinal ZIP14 mediates basolateral uptake of Mn from the bloodstream into enterocytes, contributing to Mn excretion into the intestinal lumen ( 54 Mn was administered subcutaneously, intestinal radioactivity was significantly lower in IKO mice compared to controls, indicating impaired basolateral-to-apical Mn transport
