Additionally, some RNA molecules may induce hepatotoxicity or renal toxicity due to accumulation in or clearance through the liver and kidneys, respectively, especially with repeated dosing
The downstream metabolites of the kynurenine metabolic pathway, quinolinic and kynurenic acids, are neuroactive metabolites acting on the glutamatergic N -metyl-D-aspartate (NMDA) receptor (57)
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